The Maternal Imprint by Sarah S. Richardson

Author:Sarah S. Richardson [Richardson, Sarah S.]
Language: eng
Format: epub
Tags: SCI000000 Science / General, SCI034000 Science / History, MED025000 Medical / Embryology, MED033000 Medical / Gynecology & Obstetrics, SOC028000 Social Science / Women's Studies, MED039000 Medical / History, SCI072000 Science / Life Sciences / Developmental Biology
Publisher: University of Chicago Press
Published: 2021-11-08T00:00:00+00:00

Tobi et al. (2018) “DNA Methylation as a Mediator of the Association between Prenatal Adversity and Risk Factors for Metabolic Disease in Adulthood,” Science Advances

Famine survivors’ higher BMI and triglyceride (TG), but not fasting glucose levels, are mediated by epigenetic mechanisms. One CpG mediates 13.4% of the association between prenatal famine exposure and BMI and six CpGs together mediate 80% of the association between prenatal famine and TG.

348 famine-exposed individuals, and 463 time/sibling controls

Gestation

Gestation during the famine

BMI, cholesterol, LDL/cholesterol, from medical examination, glucose from blood draw

Peripheral whole blood cells

Mixed: mediation analysis of candidate CpGs sourced from whole genome study

No

No

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